New York State Police said the woman was riding on the Northway in Saratoga County just before 8 a.m. Wednesday, June 8, when she attempted to change lanes near Curry Road in the town of Malta.
When she moved into the left lane, she struck another motorcycle and lost control before leaving the roadway and hitting a guardrail, police said.
She was taken to Saratoga Hospital, where she was declared dead.
Investigators identified the woman as Laura Covarrubias, age 38, of Glenmont.
Her companion, Raymond Suen, age 47, of Schenectady, was not injured, police said.
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